Long non-coding RNAs (lncRNAs) are a class of RNA molecules with transcript length more than 200 nt and lack of protein coding capacity, which exert their actions by many layers at the epigenetic, transcription and posttranscription level. In addition, some newly discovered miRNA and circRNA are proven to interact with lncRNAs and thereby participate in the occurrence and development of cancer. In recent years, a large number of lncRNAs have been found exhibiting aberrant expression in pancreatic cancer tissue and cells, and playing a critical role in the occurrence and development of pancreatic cancer. Therefore, the authors address the issues concerning the effects and mechanisms of some lncRNAs that are aberrantly expressed in pancreatic cancer.