Objective: To review the experience in diagnosis and treatment of isolated abdominal aortic dissection (IAAD). Methods: The clinical data of IAAD patients admitted between January 2010 and August 2015 were reviewed, which mainly concentrated on the patients’ data of the general conditions, methods of diagnosis and treatment, and survival status. Results: A total of 27 IAAD patients were enrolled. Among them, 17 cases (63.0%, 17/27) were male and 10 cases (37.0%, 10/27) were female, 9 cases (33.3%, 9/27) had concomitant hypertension, one case (3.7%, 1/27) had post-traumatic IAAD and the remaining 26 cases (96.3%, 26/27) had spontaneous IAAD. In all patients, the definite diagnosis was made by computed tomographic angiography (CTA), and all patients underwent endovascular aortic repair (EVAR) with 100% technical success. During EVAR procedure, bifurcated stent grafts were used in 20 cases (74.1%, 20/27) and straight stent grafts were used in 7 cases (25.9%, 7/27). Followed up was conducted in 26 patients (96.3%, 26/27) for an average time of (11.8±5.0) months. All the follow-up patients were alive and the CTA showed good remodeling of the abdominal aorta without complications such as endoleak, newly developed dissection or stent graft migration. Conclusion: IAAD is a rare clinical entity, with non-specific symptoms such as lower back or abdominal pain, or no symptoms at onset. EVAR is feasible treatment method for IAAD with favorable short-term outcomes, but the long-term results require further follow-up studies.