Objective: To compare the short-term efficacy of the delta-shaped anastomosis and Billroth I anastomosis in laparoscopic radical distal gastrectomy. Methods: The records of 37 patients with early-stage gastric cancer undergoing laparosicopic radical distal gastrectomy in PLA General Hospital between 2009 and 2013 were selected. Of the patients, 14 cases received delta-shaped anastomosis (delta-shaped anastomosis group) and 23 cases were subjected to Billroth I anastomosis (Billroth I anastomosis group), and the relevant intraoperative and postoperative parameters between the two groups were compared. Results: In delta-shaped anastomosis group compared with Billroth I anastomosis group, the operative time was prolonged, but the intraoperative blood loss was reduced, duration of the analgesic pump therapy, and time to first flatus and suture removal were all shortened, and all the differences had statistical significance (all P<0.05); there was no statistical difference in length of hospital stay between the two groups (P>0.05). Postoperative pathology showed that the distance of the proximal and distal surgical margins from the tumor in delta-shaped anastomosis group was significantly longer than those in Billroth I anastomosis group (both P<0.05). No statistical difference was noted in incidence of postoperative complications and adverse reactions between the two groups (P>0.05). Conclusion: The delta-shaped anastomosis can, to a certain degree, reduce the trauma and pain in patients undergoing laparoscopic radical distal gastrectomy, decrease the operative difficulty of laparoscopic surgery and the risk of infection, and promote the recovery of gastrointestinal function of the patients.