小直径腹主动脉瘤手术治疗和保守治疗疗效的Meta分析
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张显岚, Email: zhangxianlan1962@126.com

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Surgical versus conservative treatment for small-diameter abdominal aortic aneurysm: a meta-analysis
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    摘要:

    目的:系统评价手术治疗与保守治疗对小直径腹主动脉瘤(AAA)的疗效。 方法:检索国内外文献数据库,选择手术治疗(血管腔内修补术和开放手术)与保守治疗小直径AAA的随机对照实验,按照Cochrance系统评价员手册对纳入文献的方法学质量进行评价后,采用RevMan 5.1软件进行Meta分析。 结果:共纳入4个随机试验,4篇文献,共计3 314例患者,其中行血管腔内修补术和开放手术1 680例,保守治疗1 634例。Meta分析结果显示,两组之间总原因病死率(SMD=0.97,95% CI=0.68~1.38)、动脉瘤相关病死率(SMD=0.81,95% CI=0.56~1.17)、动脉瘤破裂率(SMD=0.49,95% CI=0.09~2.54,P=0.39)、术后30 d或者住院期间病死率(SMD=0.88,95% CI=0.60~1.291)差异均无统计学意义(均P>0.05)。 结论:小直径AAA手术治疗与保守治疗疗效相似,但不能确定该结论是否有临床意义,笔者经综合分析认为小直径AAA仍应积极手术治疗。

    Abstract:

    Objective: To systematically evaluate the efficacy of surgical and conservative treatment for small-diameter abdominal aortic aneurysm (AAA). Methods: The randomized controlled trails (RCTs) comparing surgical (endovascular aortic repair and open surgery) and conservative treatment for small-diameter AAA were collected by searching the national and international databases. After assessment of methodological quality of the included studies according to the Cochrane Reviewers’ Handbook criteria, Meta-analysis was performed by using RevMan 5.1 software. Results: Four RCTs were finally included, with a total of 3 314 patients, of whom 1 680 cases underwent surgical treatment and 1 634 cases underwent conservative treatment. Results of Meta-analyses showed no significance difference between the two groups of patients in all-cause mortality (SMD=0.97, 95% CI=0.68–1.38), aneurysm-related mortality (SMD=0.81, 95% CI=0.56–1.17), incidence of aneurysm rupture (SMD=0.49, 95% CI=0.09–2.54) and mortality within postoperative 30 d or during hospitalization (SMD=0.88, 95% CI=0.60–1.29) (all P>0.05). Conclusion: In treatment of small-diameter AAA, the outcomes between surgery and conservative treatment are similar. However, the clinical significance of this conclusion is uncertain, and the authors based on comprehensive analysis deem that small-diameter AAA still needs aggressive surgical treatment.

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张显岚,郭建刚.小直径腹主动脉瘤手术治疗和保守治疗疗效的Meta分析[J].中国普通外科杂志,2015,24(6):792-799.
DOI:10.3978/j. issn.1005-6947.2015.06.005

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  • 收稿日期:2015-02-14
  • 最后修改日期:2015-05-18
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  • 在线发布日期: 2015-06-15