Objective: To investigate the efficacy of open surgery for vertebral artery occlusive disease. Methods: The clinical data of 7 patients with vertebral artery occlusion admitted between 2013 and 2014 were retrospectively analyzed. All patients underwent open surgical procedures such as artery bypass operation or arterial endarterectomy, and the efficacy was evaluated according to the results of postoperative examinations and follow-up interview. Results: The symptoms were improved in all cases after surgery and then they were discharged. The surgical success rate was 100%. No perioperative complications occurred and postoperative examinations showed good blood flow in the vertebral artery. The short-term patency rate was 100%, and no recurrence of symptoms such as apparent vertigo occurred within 2-year follow up. Conclusion: Open surgery has significant efficacy in treatment of vertebral artery occlusive disease, with a higher postoperative patency rate.