Liver fibrosis characterized by excessive deposition of collagenous tissue in the liver, is the consequence of chronic liver injury of different etiologies, and may even progress to cirrhosis and liver cancer. Activation of the hepatic stellate cells (HSC) resulting in an imbalance between production and degeneration of the extracellular matrix (ECM) is an important part in the occurrence and development of liver fibrosis. Oxidative stress response as one of the important mechanisms participating in the HSC activation and ECM deposition is closely related to liver fibrosis, so using antioxidant agents for management of liver fibrosis have become the focus of interest. In this article, the authors address the recent development in antioxidant therapy for liver fibrosis.