Objective: To investigate the safety and feasibility of complete resection of the hepatic caudate lobe with ruptured hepatocellular carcinoma (HCC) via right-side approach combined with reverse staining. Methods: The clinical data of one patient with spontaneous rupture of caudate lobe HCC was retrospectively analysed and combined with relevant literature review. Results: The liver function and tumor characteristics of the patient were rigorously evaluated before operation. After exclusion of contraindications for surgery, complete resection of the caudate lobe of the patient was successfully performed via right-side approach combined with reverse staining (distinguishing the border of the caudate lobe by dyeing the posterior right hepatic lobe). No occlusion of hepatic inflow and outflow or inferior vena cava was performed during operation. Liver function of the patient recovered well after operation. No recurrence was noted in a review visit 6 months after operation. Conclusion: Complete resection of caudate lobe with spontaneous rupture of HCC via simple right-side approach combined with reverse staining is safe and feasible.