Objective: To assess the importance of multidisciplinary collaboration mode in diagnosis and treatment of severe acute pancreatitis (SAP). Methods: A multidisciplinary discussion was held for two patients, who died of SAP, the relevant literature was reviewed, and the experiences and lessons from their diagnosis and treatment were summarized. Results: SAP patients should be given organ function support in ICU during the acute stage, and minimally invasive "step-up" approach was recommended for the occurrence of infectious necrosis. Conclusion: Multidisciplinary collaborations can improve the treatment outcomes of SAP.