Objective: To investigate the clinical significance and interrelationship among intraluminal thrombus (ILT) thickness and peripheral blood concentrations of homocysteine (Hcy) and C reactive protein (CRP) in patients with abdominal aortic aneurysm (AAA). Methods: Sixty AAA patients admitted from January 2014 to December 2015 were selected, and their peripheral blood Hcy and CRP concentrations were measured by ELISA and ILT thicknesses were determined by imaging analysis. The relations of ILT thickness with clinical factors and the relationship among ILT thickness, Hcy and CRP were analyzed. Results: The proportion of cases with hypertension history, and Hcy and CRP concentrations in patients with thick ILT thickness (thickness≥7.8 mm) were significantly higher than those in patients with thin ILT thickness (thickness<7.8 mm) (all P<0.05). Correlation analysis showed that Hcy level had a significant positive correlation with ILT thickness (r=0.942), the ratio of ILT thickness to AAA maximum diameter (r=0.844), and AAA maximum diameter (r=0.505) (all P<0.05), while CRP level had no significant correlation with other factors (all P>0.05). Conclusion: ILT thickness and peripheral blood Hcy and CRP concentrations are all potential risk factors for AAA progression. Further, there may be a mutual promotion between ILT thickness and Hcy concentration.