Pancreatic cancer is one of the digestive malignancies with the worst prognosis and therefore, how to provide scientific and standard treatment for pancreatic cancer is a hot topic in the field of surgery. In this article, the authors discuss the similarities and differences in the treatment strategies between the “potentially curable pancreatic cancer” in the ASCO guideline and the “resectable and borderline resectable pancreatic cancer” in the NCCN guideline from five aspects: preliminary assessment, surgical indications, preoperative management, postoperative treatment and follow-up surveillance.