Objective: To investigate the value of using enhanced recovery after surgery (ERAS) programs in liver resection for hepatolithiasis. Methods: The clinical data of 178 patients undergoing liver resection for hepatolithiasis with ERAS management (ERAS group) from January 2013 to December 2016 and 218 patients undergoing liver resection for hepatolithiasis with conventional perioperative management (conventional group) from January 2009 to December 2012 were retrospectively analyzed. The main clinical variables between the two groups of patients were compared. Results: In ERAS group compared with conventional group, the recovery of liver function parameters after surgery was faster (partial P<0.05), the length of postoperative hospital stay was significantly shortened, the time to first flatulence was significantly reduced, the postoperative body weight loss was significantly decreased and the total hospitalization cost was significantly reduced (all P<0.05). There were no statistical differences either in incidence of overall postoperative complications or incidence of specific complication between the two group (all P>0.05). No death occurred in either of the groups. Conclusion: Using ERAS protocol in liver resection for hepatolithiasis is safe and feasible. It can effectively promote the postoperative recovery of the patients, and reduce the length of hospital stay and medical cost.