胃癌组织YAP1、E-cadherin、N-cadherin表达及临床意义
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陈子华, Email: zihuac@126.com

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湖南省自然科学基金资助项目(2015JJ4049)。


Expressions of YAP1, E-cadherin and N-cadherin in gastric cancer tissue and their clinical significance
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    摘要:

    目的:探讨YAP1、E-cadherin、N-cadherin在胃癌组织中表达及意义。 方法:用免疫组化法检测胃癌组织芯片中135例患者癌组织和癌旁组织中YAP1、E-cadherin、N-cadherin表达,分析YAP1表达与E-cadherin、N-cadherin表达的关系,以及与胃癌患者临床病理因素以及预后的关系。 结果:与癌旁组织比较,胃癌组织中YAP1表达明显升高,E-cadherin表达明显降低(均P<0.05),N-cadherin表达无明显差异(P>0.05);在胃癌组织中,YAP1表达与E-cadherin表达呈负相关 (r=-0.273,P=0.032),与N-cadherin表达呈正相关(r=0.304,P=0.019)。YAP1在胃癌组织中的表达与胃癌患者淋巴转移、脉管侵犯有关(均P<0.05),且YAP1阳性表达患者总生存率明显低于阴性表达患者(χ2=4.354,P=0.037)。 结论:YPA1与E-cadherin在胃癌组织中表达有明显变化,YAP1高表达与胃癌患者不良临床病理特征及预后密切相关。

    Abstract:

    Objective: To investigate the expressions of YAP1, E-cadherin and N-cadherin in gastric cancer tissue and their significance. Methods: The expressions of YAP1, N-cadherin and E-cadherin proteins in tissue microarray containing 135 samples of gastric cancer tissue and adjacent tissue were determined by immunohistochemical staining. The relations of YAP1 expression with E-cadherin and N-cadherin expressions as well as with clinicopathologic characteristics and prognosis of the patients were analyzed. Results: In gastric cancer tissue compared with adjacent non-tumor tissue, the YAP1 expression was increased and E-cadherin expression was decreased significantly (both P<0.05), but the N-cadherin showed no significant difference (P>0.05). There was a negative correlation between YAP1 expression and E-cadherin expression (r=–0.273, P=0.032), and a positively correlation between YAP1 expression and N-cadherin (r=0.304, P=0.019) in gastric cancer tissue. The expression of YAP1 in gastric cancer was correlated with lymphatic metastasis and vascular invasion (P<0.05), and the overall survival rate in patients with YAP1 positive expression was significantly lower than that in those with YAP1 negative expression (χ2=4.354, P=0.037). Conclusion: The expressions of YPA1 and E-cadherin are significantly changed in gastric cancer tissue, and high YAP1 expression is closely related to the unfavorable clinicopathologic features and poor prognosis in the gastric cancer patients.

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肖磊|黄昌浩|袁伟杰|陈晋湘|骆晴晴|陈子华.胃癌组织YAP1、E-cadherin、N-cadherin表达及临床意义[J].中国普通外科杂志,2018,27(4):442-448.
DOI:10.3978/j. issn.1005-6947.2018.04.009

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  • 收稿日期:2017-12-26
  • 最后修改日期:2018-03-13
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  • 在线发布日期: 2018-04-15