Objective: To investigate the clinical treatment of chronic venous lower-extremity ulcers and the treatment efficacy. Methods: The clinical data of 48 patients with chronic venous leg ulcers treated from March 2014 to September 2015 were retrospectively analyzed. The treatment modalities included the correction of the primary causal disease, drug therapy, physiotherapy, high ligation of the greater saphenous vein plus stripping, circular ligation around ulcers, combined free skin flap coverage for those with large ulcer area (≥48.0 cm2), and long-term use of elastic stockings to promote venous blood return after ulcer surface healing. Results: After treatment, complete primary healing was achieved in 12 patients (25.0%), of whom, all the skin grafts survived in the 5 patients with large ulcer area; ulcer healing area of more than 70% was achieved in 27 patients (56.3%), and also reached 50% in the remaining 9 patients (18.7%). The average length of hospitalization was 17.8 d. Patients with residual leg ulcers received sterile dressings by regular clinic visits. The patients were followed up for 3 to 12 months and all ulcers were healed with an average healing time of 1.5 months. Conclusion: Based on the correction of the primary causal disease, the integrated multi-therapy approach combined with surgical treatment for chronic venous leg ulcers has satisfactory effect for fast ulcer healing and low recurrence.