Objective: To compare the clinical effects of different hepatic blood occlusion procedures in external capsule excision for hepatic cystic echinococcosis. Methods: Fifty-six patients with hepatic cystic echinococcosis undergoing external capsule excision were enrolled. Of the patients, 31 cases underwent hepatic blood inflow occlusion by Glisson’s pedicle ligation (Glisson’s pedicle occlusion group), and 25 cases underwent hepatic blood inflow occlusion by Pringle’s procedure (Pringle group). The main clinical variables between the two groups of patients were compared. Results: The preoperative data were comparable between the two groups of patients. There were no significant differences in operative time, occlusion time, intraoperative blood loss, amount of postoperative drainage and hospitalization cost between the two groups of patients (all P>0.05), but the time to postoperative anal gas passage and length of postoperative hospital stay in Glisson’s pedicle occlusion group were significantly shorter than those in Pringle group (both P<0.05). As for the liver function parameters, the postoperative alanine transaminase and aspartate transaminase levels in Glisson’s pedicle occlusion group were significantly lower than those in Pringle group (both P<0.05), but no significant difference were noted in postoperative total bilirubin levels between the two groups (P>0.05). There were no significant differences in prothrombin time and stress response indicators such as C-reactive protein, HOMA-IR index and tumor necrosis factor α between the two groups (all P>0.05). Conclusion: Hepatic blood inflow occlusion by method of Glisson’s pedicle ligation can promote the postoperative liver function recovery in patients with hepatic cystic echinococcosis undergoing external capsule excision compared with that by Pringle’s procedure.