Gallbladder cancer is a common biliary malignancy and one of the most aggressive tumors of the digestive system. Surgical treatment is effective for early stage gallbladder cancer, but radical surgery is always difficult or impossible for advanced stage gallbladder cancer, due to the spread of tumor cells to the lymph nodes, hepatic hilar area, or other organs, resulting in poor prognosis and short survival. The authors address the current research status and progress in treatment of gallbladder cancer for reference use in clinical practice.