Infected pancreatic necrosis (IPN) is a serious complication of acute pancreatitis and it is also a leading cause of death. Minimally invasive debridement of the necrotic pancreatic tissue combined with antibiotics is currently the main treatment method for IPN. IPN is mostly involving hospital-acquired infections, with complex spectrum, frequent multidrug-resistant bacteria, and difficult choice of antibiotics. At present, the clinical data on the pathogens and drug resistance of IPN patients are limited, so understanding the risk factors for its occurrence, bacterial spectrum, drug resistance and related prognosis can provide better diagnosis and treatment for these patients.