Single-site endoscopic thyroidectomy (SSET) emerged from the development of endoscopic thyroid surgery and the growth of aesthetic requirements of the patients. SSET has both advantages of being minimally invasive and cosmetic in addition to its per se safety and effectiveness, which follows the mainstream trend of modern surgery. In recent years, SSET has developed rapidly, especially in East Asia, but there are still many issues that need to reach an agreement, including the choice of surgical approach, the improvement of operational skills, the renewal of concepts, and the development of surgical equipment. At present, personalized SSET plan should be provided to the patients according to both doctor's skills and patient's specific condition.