Pancreatic cancer is the most malignant tumor of the digestive system. The diagnosis and treatment of pancreatic cancer have always been hot and difficult problems, and the concepts for its treatment are continuously being updated and improved in an arduous journey of exploration. At present, the hot issues of pancreatic cancer in clinical research include the transformation of multiple disciplinary team model in the treatment of pancreatic cancer, the definition of potentially resectable pancreatic cancer, the application of neoadjuvant chemotherapy, the way to improve the R0 resection, the utilization of minimally invasive surgery and the application value of enhanced recovery after surgery. Here, the above-mentioned issues are discussed, based on the latest literature and the authors’ own experience.