Objective: To investigate the clinical characteristics, treatment and prognosis of  solid pseudopapillary tumor of the pancreas (SPTP).
Methods: The clinical data of 47 patients treated and pathologically confirmed as SPTP in the Department of General Surgery of the First Affiliated Hospital of Nanchang University from January 2007 to December 2018 were retrospectively analyzed.  
Results: Of the whole group, 11 patients were males and 36 were females, with the mean age of (32±15) years; the tumor was located in the head of the pancreas in 16 cases, in the neck of the pancreas in 8 cases, and in the body and tail of the pancreas in 23 cases; 21 cases (44.7%) were preliminarily diagnosed as SPTP by preoperative imaging examinations, and 6 cases underwent endoscopic ultrasound-guided fine-needle aspiration, by which, only 1 case (16.7%) was diagnosed as SPTP; 10 cases underwent pancreaticoduodenectomy, 12 cases underwent distal pancreatectomy combined with splenectomy, 8 cases underwent spleen-preserving distal pancreatectomy, 5 cases underwent middle segmental pancreatectomy, 10 cases underwent tumor enucleation, 1 case underwent duodenum-preserving pancreatic head resection, and 1 case underwent distal pancreatectomy combined with splenectomy, left nephrectomy, left adrenalectomy, and inferior vena cava thrombectomy. No reoperation was required and no death occurred in any of the patients. Immunohistochemical staining of the tumor specimens showed that positive expressions of PR, CD56 and NSE presented in most of them. The incidence of postoperative complications was 19.1% (9/47). Postoperative followed-up was conducted in 43 patients for (41.7±31.4) months, recurrence occurred in 1 patient and all these patients were alive.
Conclusion: SPTP is a potential low-grade malignant tumor, which is more likely to occur in young women. Its clinical manifestations are non-specific, and the diagnosis depends on histopathological examination. Surgical resection is the favored option, with a good prognosis.