Pancreatic fluid collections (PFC) are common complications of severe acute pancreatitis (SAP). They often cause systemic inflammatory response syndrome (SIRS) and intra-abdominal hypertension (MOF), and even abdominal compartment syndrome (ACS) which is difficult to be corrected, and thereby develop multiple organ failure (MOF) and death. With the deepening of pathophysiological research and emergence of a large number of evidence-based medical data of SAP, the concept of minimally invasive and injury-control staged treatment of SAP has been confirmed and recommended by most guiding documents. However, puncture timing and location of percutaneous catheter drainage (PCD) guided by ultrasound or CT as the initial and core minimally invasive method for PFC are still controversial. How to achieve the “individualized” and “accurate” management of patients according to the guidelines remains to be further explored.