Colorectal cancer (CRC) is the third most common malignant tumor in the world. Despite many advances in understanding the pathogenesis, pathology, prevention and treatment of CRC, there is still a high mortality rate. The mortality rate is closely related to CRC liver metastasis. Therefore, studying the mechanism of liver metastasis and controlling disease progression are important measures to improve the survival time of these patients. In recent years, mouse models of CRC liver metastasis have been widely used in metastasis research. Here, the authors address the current mouse models and their characteristics, and analyze their advantages and disadvantages. It is expected to provide references for investigators in selecting the mouse CRC liver metastasis model, and clues for the study of the mechanism of CRC liver metastasis.