spectively analyzed. The clinicopathologic characteristics of the patients were summarized. The clinical and pathological factors for lymphatic metastasis of the patients were determined by univariate and multivariate analysis.
Results: Among the 50 patients, the proportion of females was higher than that of males (male to female ratio was 2:3); 7 cases had no symptoms, 43 cases presented with different degrees of upper abdominal pain, nausea/vomiting, tiredness, weight loss and anorexia, and 32 cases (64.0%) had lymphatic metastasis. Results of univariate analysis showed that tumor location, T stage, histological grade, distant metastasis, vascular invasion, hepatic invasion and serum CEA level were significantly associated with lymph node metastasis of the patients (all P<0.05). Results of Logistic multivariate regression analysis showed that tumor location, T stage, histological grade and distant metastasis were independent risk factors for lymphatic metastasis of gallbladder cancer patients (all P<0.05).  
Conclusion: Women account for a relatively high proportion of the patients with gallbladder cancer,  and lymph node metastasis is common. Many factors are closely associated with lymph node metastasis of the patients. In these patients, the lymphatic tissue should be carefully cleared during operation to avoid local recurrence and distant metastasis, and thereby prolong their survival time.