Objective: To investigate the application efficacy of the concept of enhanced recovery after surgery (ERAS) in perioperative period of hepatectomy. 
Methods: Ninety-seven patients undergoing liver resection in Fuyang People's Hospital from February 2014 to December 2018 were enrolled, and were randomly allocated to ERAS group (49 cases) and control group (48 cases). Patients in ERAS group received perioperative management directed by ERAS concept, and those in control group underwent perioperative management with a conventional protocol. The main clinical variables were compared between the two groups.
Results: There were no significant differences in general data between the two groups (all P>0.05). In ERAS group compared with control group, the operative time was significantly prolonged [(186.18±51.31) min vs. (157.00±66.53) min, P=0.02], but the intraoperative blood loss and proportion of blood transfusion showed no significant differences (both P>0.05); the time to postoperative tube removal [(6.04±2.09) d vs. (8.44±2.97)d], time to anal gas passage [(1.96±0.79) d vs. (2.52±1.26) d] and length of postoperative hospital stay [(8.57±3.21) d vs. (11.54±4.82) d] were all significantly reduced (all P<0.05); the incidence of postoperative complications was significantly decreased (20.4% vs. 60.4%, P=0.001). 
Conclusion: Using ERAS protocol in perioperative management of hepatectomy in the treatment of liver diseases is safe and effective, and it can also reduce the occurrence of postoperative complications and promote the postoperative recovery of patients. It is recommended to be used in clinical practice.