多梳蛋白4与含FERM结构域蛋白4A在胃癌组织中的表达及与意义
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周海宁, Email: zhouhaining72@163.com

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R735.2

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甘肃省自然科学基金资助项目(1506RJZA309)。


Expressions of chromobox homolog 4 and FERM domain-containing protein 4A in gastric cancer tissue and their significance
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    摘要:

    目的:探讨胃癌组织中多梳蛋白4(Cbx4)和含FERM结构域蛋白4A(FRMD4A)表达及其与胃癌患者临床病理参数及预后的关系。
    方法:收集2010年2月—2013年11月收治的112例胃癌患者的手术标本(癌组织及癌旁组织)及临床病理资料,用qRT-PCR和免疫组化法中检测标本中Cbx4、FRMD4A mRNA与蛋白表达;分析胃癌组织Cbx4和FRMD4A蛋白表达水平与临床病理参数及生存率的关系,并分析影响胃癌预后的因素。
    结果:与癌旁正常组织比较,胃癌组织中Cbx4和FRMD4A mRNA与蛋白表达水平均明显升高(均P<0.05)。Cbx4及FRMD4A蛋白表达水平与胃癌患者T分期、N分期、分化程度及远处转移明显有关(均P<0.05);Cbx4、FRMD4A蛋白阳性表达组胃癌患者5年生存率均明显低于各自阴性表达组患者(χ2=15.42,P=0.000;χ2=21.55,P=0.000)。Cox多因素分析显示,Cbx4(HR=2.754,95% CI=1.827~4.151,P=0.000)和FRMD4A(HR=3.129,95% CI=2.282~4.290,P=0.000)蛋白表达水平以及T分期(HR=1.432,95% CI=1.241~1.652,P=0.005)、远处转移(HR=1.257,95% CI=1.208~1.308,P=0.032)是影响胃癌患者预后的独立危险因素。
    结论:Cbx4及FRMD4A在胃癌组织中高表达,且与患者的不良临床病理特征及预后密切相关,可能对胃癌病情评估及预后判断有一定意义。

    Abstract:

    Objective: To investigate the expressions of chromobox homolog 4 (Cbx4) and FERM domain protein 4A (FRMD4A) in gastric cancer tissue and their relations with the clinicopathologic parameters and prognosis of the gastric cancer patients.
    Methods: The surgical specimens (cancer and adjacent tissues) and clinicopathologic data of 112 patients with gastric cancer treated from February 2010 to November 2013 were collected. The mRNA and protein expressions of Cbx4 and FRMD4A in the specimens were determined by qRT-PCR and immunohistochemical staining. The relations of the protein expressions of Cbx4 and FRMD4A with the clinicopathologic variables and survival rates of the patients were analyzed, and the prognostic factors for gastric cancer patients were also analyzed.
    Results: Compared with tumor adjacent normal tissue, both mRNA and protein expression levels of Cbx4 and FRMD4A in gastric cancer tissue were significantly increased (all P<0.05). The protein expression levels of both Cbx4 and FRMD4A were significantly associated with the T stage, N stage, degree of differentiation and distant metastasis of the patients (all P<0.05). The 5-year survival rate in gastric cancer patients with positive expression of Cbx4 or FRMD4A protein was significantly lower than that in those with corresponding negative expression (χ2=15.42, P=0.000; χ2=21.55, P=0.000). Cox multivariate analysis showed that the protein expression levels of Cbx4 (HR=2.754, 95% CI=1.827–4.151, P=0.000) and FRMD4A (HR=3.129, 95% CI=2.282–4.290, P=0.000) as well as T stage (HR=1.432, 95% CI=1.241–1.652, P=0.005) and distant metastasis (HR=1.257, 95% CI=1.208–1.308, P=0.032) were independent risk factors affecting the prognosis of gastric cancer patients.
    Conclusion: The Cbx4 and FRMD4A expressions are increased in gastric cancer tissues, which are closely related to the unfavorable clinicopathologic features and prognosis of patients. They may have certain significance in disease assessment and prognosis estimation for gastric cancer patients. 

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钱海权, 周海宁, 刘轲, 赵伟.多梳蛋白4与含FERM结构域蛋白4A在胃癌组织中的表达及与意义[J].中国普通外科杂志,2019,28(10):1237-1244.

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  • 收稿日期:2019-08-23
  • 最后修改日期:2019-09-24
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  • 在线发布日期: 2019-10-25
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