Objective: To investigate the clinicopathologic features and prognosis as well as the relevant influential factors of primary breast angiosarcoma.
Methods: According to the inclusion and exclusion criteria, the data of patients with primary breast angiosarcoma were downloaded from the SEER database. The clinicopathologic characteristics and survival status of the patients were analyzed. The influential factors for prognosis were determined by univariate and multivariate Cox regression analysis.
Results: Of the selected 166 patients with primary breast angiosarcoma, 55.4% (92/166) were women under 53 years old, 75.9% (126/166) had no metastasis at diagnosis, 97.0% (161/166) underwent surgery, 34.3% (57/166) received radiotherapy, and 31.3% (52/166) received chemotherapy. The 1-year overall survival rate of the entire group was 85.47%. The survival rates were significantly different among patients with different ages, stages, degrees of differentiation and tumor sizes and undergoing different surgical procedures as well as between patients with single primary tumor and multiple primary tumors (all P<0.05). Univariate analysis showed that age, differentiation, stage, multiple primary tumors, surgical procedure, and the maximum diameter of the lesion were significantly associated with the prognosis of the patients with primary breast angiosarcoma (all P<0.05). Multivariate analysis revealed that old age, poor differentiation, advanced stage, multiple primary cancers, and high tumor load were independent risk factors for prognosis of the patients with primary breast angiosarcoma (all P<0.05).
Conclusion: Primary breast angiosarcoma has an unfavorable prognosis, and early diagnosis and treatment of primary breast angiosarcoma can reduce tumor progression and improve prognosis. Adjuvant radiotherapy and chemotherapy exert no significant effect on prognosis of the patients.