cN0甲状腺微小乳头状癌右侧喉返神经后方淋巴结转移及清扫研究进展
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刘静, Email: liujing5585@163.com

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Progress of metastasis and dissection of the lymph nodes posterior to the right recurrent laryngeal nerve in cN0 thyroid micropapillary carcinoma
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    摘要:

    在我国甲状腺微小乳头状癌(PTMC)约占新发甲状腺乳头状癌(PTC)的74.8%,尽管PTMC预后良好,但部分PTMC患者在早期就出现淋巴结转移甚至远处转移,其中30.7%~49.2%的cN0 PTMC患者出现中央区淋巴结转移(CLNM)。我国关于分化型甲状腺癌指南建议在有技术保障的前提下,对cN0 PTMC患者行病灶同侧中央区淋巴结清扫(CLND);而美国甲状腺协会最新指南指出预防性中央区淋巴结清扫(pCLND)不能改善患者长期生存率,还有可能增加并发症的发生率。由此可见,cN0 PTMC是否行pCLND尚存在争议。支持者认为对PTMC行pCLND可减少局部复发,病理结果可提高患者TNM分期的准确性,有利于后期为患者制定个体化的治疗方案。反对者认为是否行pCLND对PTMC患者预后没有影响,反而会增加损伤甲状旁腺和喉返神经(RLN)的风险。右侧中央区淋巴结分为RLN上方淋巴结(VIa)和RLN后方淋巴结(VIb),VIb区淋巴结位置较深,解剖空间狭窄,其特殊的解剖特点导致术前评估难以预测其转移情况,术中完整解剖该区域的淋巴及脂肪组织可能会导致RLN损伤、胸膜破裂、乳糜漏等多种并发症。然而,cN0 PTMC患者CLNM和VIb区淋巴结转移发生率达30.7%~49.2%,不容忽视。对有高危因素的cN0 PTMC患者行pCLND可避免因肿瘤复发而再次手术,再次手术不仅难度加大,而且并发症的发生率也会大大增加。因此,探讨VIb区淋巴结转移危险因素意义重大,cN0 PTMC患者VIb区淋巴结转移危险因素可能包括年龄<45岁、男性、肿瘤直径>0.5 cm、多灶性、肿瘤置于右侧腺体上级、侵出包膜、腺外浸润、合并结节性甲状腺肿以及VIa区淋巴结转移等。笔者对cN0 PTMC患者VIb区淋巴结转移及清扫进行综述。

    Abstract:

    Thyroid micropapillary carcinoma (PTMC) accounts for about 74.8% of newly diagnosed thyroid papillary carcinoma (PTC) in China. Although PTMC has an excellent prognosis, some PTMC patients will develop early lymph node metastasis or even distant metastasis. For instance, about 30.7% to 49.2% of patients with cN0 PTMC have central lymph node metastasis (CLNM). China’s guideline for differentiated thyroid cancer suggests that ipsilateral central lymph node dissection (CLND) should be performed for patients with cN0 PTMC on the premise of the effective technical guarantee. However, the latest guideline of the American Thyroid Association points out that prophylactic central lymph node dissection (pCLND) is ineffective in improving long-term survival, but may increase the incidence of complications. So, whether or not performing a pCLND for cN0 PTMC patients is still controversial. The supporters think that pCLND can reduce local recurrence, and the results of pathological examination can improve the accuracy of TNM staging, which may help make the individualized treatment plan for the patients after operation. The opponents argue against pCLND, as it does not improve the prognosis, but increases the risk of hypoparathyroidism and recurrent laryngeal nerve (RLN) injury. Right central lymph nodes are divided into lymph nodes superior to the RLN (VIa) and lymph nodes posterior to the RLN (VIb). The level VIb lymph nodes are locate in deep tissue, with a narrow anatomical space, and these anatomical characteristics make it difficult to predict the metastasis of them in preoperative assessment, and complete dissection of the lymphatic and adjacent adipose tissues in this area during surgery may cause various complications, such as RLN injury, pleural rupture, and chylous fistula. However, the incidence rates of CLNM and VIb level lymph node metastasis in cN0 PTMC patients reach 30.7% to 49.2%, which should not be ignored. Performing pCLND in cN0 PTMC patients with high-risk characteristics can avoid the repeated operation for tumor recurrence. The difficulty of reoperation is increased and the incidence of complications will also be greatly increased. Therefore, identification of the risk factors of VIb lymph node metastasis is of great significance. The risk factors for VIb lymph node metastasis in cN0 PTMC patients may include patient age <45 years, male sex, tumor diameter larger than 0.5 cm, multifocality, upper pole location, capsular invasion, extrathyroidal extension, concomitant nodular goiter and VIa lymph node metastasis, et al. Here, the authors address the metastasis and dissection of the VIb level lymph nodes in cN0 PTMC patients.

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王慧芳, 于博, 赵文君, 刘静. cN0甲状腺微小乳头状癌右侧喉返神经后方淋巴结转移及清扫研究进展[J].中国普通外科杂志,2020,29(5):603-610.
DOI:10.7659/j. issn.1005-6947.2020.05.012

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  • 收稿日期:2019-11-29
  • 最后修改日期:2020-04-19
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  • 在线发布日期: 2020-05-25