Background and Aims: Insulinoma is the most common functional islet-cell tumor of the pancreas, and surgery is the only cure for this condition. With the development of technology and equipment, laparoscopic surgery has been accepted by doctors and patients. This study was conducted to evaluate the feasibility and efficacy of laparoscopic insulinoma enucleation. 
Methods: The perioperative clinical data and follow-up results of 11 patients who underwent laparoscopic insulinoma resection in the authors’ institute from July 2016 to May 2019 were retrospectively analyzed.
Results: Among the 11 patients, there were 4 males and 7 females. The patients were aged 21-62 years with an average age of 44.8 years at the time of hospital attendance. The course of disease ranged from 8 d to 4 years, and all patients were diagnosed with insulinoma according to preoperative qualitative and localization examinations. Laparoscopic tumor resection was successfully performed in 10 patients, including tumor enucleation in 8 patients (2 with tumor located in the neck of the pancreas, 5 cases in the body, and 2 cases in the tail), and resection of the body and tail of the pancreas in 2 patients (1 case in the body, and 2 cases in the tail). Intraoperative laparoscopic ultrasound examination was performed in all the 11 patients, by which, a total of 11 tumors were detected in 10 cases, and no lesion was found in 1 case, so the operation was aborted. The operative time was 85.0–380.0 min, and intraoperative blood loss was 10.0–530.0 mL. At 30 min after tumor resection, the blood glucose increased by 1.5–2.3 mmol/L; blood glucose was 3.9–10.4 mmol/L on the first postoperative day in the morning, and 2.4–12.8 mmol/L at discharge from hospital. Postoperative pathology reported benign insulinoma for all patients. Postoperative complications occurred in 3 patients, including pancreatic fistula (grade A) in 1 patient and rebound hyperglycemia in 2 patients. The length of postoperative hospital stay was 5.0–15.0 d. Follow-up was conducted for 10 to 43 months, and the hypoglycemia symptoms completely disappeared and no tumor recurrence was observed in the 10 patients with complete tumor resection.
Conclusion: Laparoscopic resection is safe, effective and minimally invasive for benign insulinoma located in the surface of pancreatic neck, body or tail and benign insulinoma suitable for pancreatic body and tail resection. So, it is recommended to be used in clinical practice.