不同类型减重代谢手术治疗重度肥胖合并2型糖尿病的近期疗效分析
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罗衡桂, Email: hyhg006@163.com

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湖南省湘潭市医学科研基金资助项目(2019xtyx-2)。


Analysis of short-term efficacy of different types of bariatric-metabolic surgeries for severe obesity with type 2 diabetes mellitus
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    摘要:

    背景与目的:减重代谢手术是肥胖合并2型糖尿病(T2DM)的有效治疗方式,但不同的减重代谢手术在治疗肥胖症和控制血糖等方面效果不同。因此,本研究探讨不同减重代谢手术方式治疗重度肥胖合并T2DM的短期疗效,以及它们在减重、降糖、降脂等方面的特点,以期为临床治疗选择提供参考。
    方法:回顾分析63例行减重代谢手术重度肥胖合并T2DM患者的临床资料。其中25例行腹腔镜胃袖状切除(LSG),18例行LSG+空肠旁路术(LSG+JJB),20例行腹腔镜胃旁路术(LRYGB),比较三组患者术前及术后6、12个月的临床数据。
    结果:三组术前各项资料具有可比性。所有患者均顺利完成手术,三组手术时间比较差异有统计学意义(P<0.05),其余手术相关指标差异均无统计学意义(均P>0.05)。三组术后体质量、腰围、臀围、BMI、多余体质量减少百分比(%EWL)等减重指标均较术前明显改善(均P>0.05),除臀围在同组术后6个月与12个月以及三组间术后相同时间点差异均无统计学意义外(均P>0.05),其余4项指标均为同组术后12个月明显优于术后6个月、同时间点LSG+JJB组与LRYGB组优于LSG组(均P<0.05),而LSG+JJB组与LRYGB组间差异无统计学意义(均P>0.05)。三组患者术后空腹血糖、空腹胰岛素、糖化血红蛋白、胰岛素抵抗指数等糖代谢指标均较术前明显改善(均P<0.05),但以上指标在同组术后6个月与12个月间以及三组同时间点差异均无统计学意义(均P>0.05);三组术后6、12个月糖尿病缓解率比较,差异均无统计学意义(均P>0.05)。三组患者术后血胆固醇、甘油三脂、低密度脂蛋白、高密度脂蛋白、尿酸等脂代谢指标均较术前明显改善(均P<0.05),三组间甘油三脂、高密度脂蛋白、低密度脂蛋白改善效果差异无统计学意义(均P>0.05),LRYGB组、LSG+JJB组血尿酸及胆固醇降低程度均优于LSG组(均P<0.05)。
    结论:LSG、LSG+JJB、LRYGB均有良好的减重及改善糖脂代谢作用,短期效果显著;三者均能有效降低血糖、血脂指标。LSG+JJB和LRYGB的减重、降尿酸、降胆固醇的效果优于LSG。LSG+JJB手术操作简单,效果明显,值得在临床中进一步推广运用。

    Abstract:

    Background and Aims: Bariatric-metabolic surgeries are effective treatment for severely obese patients with type 2 diabetes mellitus (T2DM). However, different types of bariatric-metabolic surgeries have different effects on aspects such as weight reduction and blood glucose control. Therefore, this study was conducted to investigate the short-term efficacy of different types of bariatric-metabolic surgeries for severely obese patients with T2DM, and their characteristics in terms of reducing weight, sugar and lipid, so as to provide treatment options for clinical use. 
    Methods: The clinical data of 63 patients with severe obesity and concomitant T2DM undergoing bariatric-metabolic surgery were retrospectively analyzed. Of the patients, 25 cases underwent laparoscopic sleeve gastrectomy (LSG), 18 cases underwent LSG plus jejuno-jejunal bypass surgery (LSG+JJB), and 20 cases underwent laparoscopic Roux-en-Y gastric bypass surgery (LRYGB). The clinical data before surgery and 6 and 12 months after surgery among the three groups of patients were compared. 
    Results: The preoperative data were comparable among the three groups. Operations were successfully completed in all patients. Among the three groups, the operative times were significantly different (P<0.05), but all other surgery-related variables showed no significant differences (all P>0.05). The weight loss variables that included the body weight, waist circumference, hip circumference, BMI and the percentage of excess weight loss (%EWL) in the three groups after surgery were significantly improved compared to those before surgery (all P<0.05), in which, the hip circumference showed no significant difference between postoperative 6 and 12 months in the same groups as well as among groups at the same time points (all P>0.05), while all the remaining 4 variables were significantly better at postoperative 12 months than those at 6 months in the same groups, and were significantly better in LSG+JJB group and LRYGB group than those in LSG group (all P<0.05), but showed no significant differences between LSG+JJB group and LRYGB group (all P>0.05). The indexes of glucose metabolism that included the fasting plasma glucose, fasting insulin, glycated hemoglobin, insulin resistance index in the three groups after surgery were significantly improved compared to those before surgery (all P<0.05), but there were no significant differences in these indexes between postoperative 6 and 12 months as well as among groups at the same time points (all P>0.05); the diabetes remission rates at 6 and 12 months after surgery showed no significant difference among the three groups (both P>0.05). The parameters of lipid metabolism that included the blood cholesterol, triglyceride, low-density lipoprotein, high-density lipoprotein and uric acid in the three groups after surgery were improved compared to those before surgery (all P<0.05), and the degrees of improvement in triglyceride, high-density lipoprotein, and low-density lipoprotein were similar in the three groups (all P>0.05), but the decreasing amplitudes in blood uric acid and cholesterol in LRYGB group and LSG+JJB group were significantly greater than those in LSG group (all P<0.05). 
    Conclusion: All LSG, LSG+JJB and LRYGB have good short-term efficacy in reducing weight and improving glucose and lipid metabolism. They have similar effects of reducing blood glucose and some lipid parameters. LSG+JJB has the same effect as LRYGB and both are superior to LSG in reducing weight, uric acid and cholesterol. LSG+JJB is simple in operation with demonstrable efficacy. So, it is recommended to be used in clinical practice.

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罗衡桂, 唐彬, 毛岳峰, 陈伟, 张晓玲, 李绍杰, 姜学润, 陈香林, 郭进, 王力, 张全安, 林慧, 夏佩, 张水湘.不同类型减重代谢手术治疗重度肥胖合并2型糖尿病的近期疗效分析[J].中国普通外科杂志,2020,29(10):1224-1233.
DOI:10.7659/j. issn.1005-6947.2020.10.009

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  • 收稿日期:2020-05-09
  • 最后修改日期:2020-09-12
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  • 在线发布日期: 2020-10-25