Abstract:Abstract:Objective To study the significance and expression relationship among STAT1,STAT2 and hMLH1,hMSH2 proteins in hepatocellur carcinoma(HCC).
Methods SABC immunohistochemistry method was used to detect the expression of STAT1,STAT2,hMLH1 and hMSH2 proteins in cancer tissues and paracancer tissue from 37 patients of HCC.
Results The positive rates and expressive levels of STAT1,STAT2,and hMLH1, hMSH2 in HCC was significantly lower than those in paracancer liver tissues(P<0.05). The level of expression of the 4 proteins in welldifferented cancer tissue was significanty higher than that in poorly differentiated cancer tissue(P<0.05). A positive correlation was found for STAT1 and hMSH2,STAT2 and hMLH1,hMSH2 (P<0.05) in paracancer liver tissues.
Conclusions The data suggest that STAT1,STAT2 and hMLH1,hMSH2 may play an important roie in the early stage of malignant transformation of hepatocytes.