Abstract:Objective
To study the relationship of hepatocyte apoptosis and gene expression of liver cirrhosis and primary hepatic carcinoma.
Methods Specimens of liver tissue from patients with liver cirrhosis and portal hypertension and normal subjects were examined by transmission electron microscope to detect apoptotic cells and primary cancer gene expression.
Results The number of apoptotic cells and the apoptotic index of cirrhotic liver tissue was higher than that of normal subjects.Immunostaining of bcl2,cmyc,cfos was negative in normal liver tissue,but was overexpressed in cirrhosis.
Conclusions Hepatocyte apoptosis plays a certain role in the development of hepatic cirrhosis. The oncogenes bcl2,cmyc,cfos take part in the regulation of hepatocyte apoptosis.