Abstract:Objective：To study a rational method of pancreaticojejunostomy after pancreatoduodenectomy. Methods：Retrospective analysis was made on the clinical material of 108 cases of bundle-invagination pancreaticojejunostomy after pancreatoduodenectomy performed from Jan 1996 to Dec 2003 in our department. Results：The operative time was 3.5~4.5 hours. No perioperative death nor pancreatic fistula occurred. One diabetic patient developed biliary fistula on the 8th post-operative day and it healed spontaneously after drainage. Two cases had wound dehiscence that healed after tension relaxation suture. Two cases of postoperative gastroparesis recovered after conservative treatment.Conclusions：The bundle-invagination pancreaticojejunostomy can more effectively prevent pancreatic fistula and have less operation time.