Abstract:Objective：To explore the etiology, mechanism and treatment of diarrhea after pancreatoduodenectomy. Methods：Based on the clinical data of 159 cases of pancreatoduodenectomy performed in the recent one and half years, the pathogenesis of post-pancreatoduodenectomy diarrhea was analyzed and the effect of different treatments was observed. Results：Seventy-one cases had diarrhea, with an incidence of 44.7%. Tweenty-two cases had bacterial infection of the intestinal tract and 4 cases had fungus infection. The incidence of infection was 36.6%. In 64 cases diarrhea was relieved with effective treatment, accounting for 90.1% of all cases. Seven cases with chronic diarrhea had additional treatment with oral pancreatic enzyme and symptoms were relieved 2 weeks after treatment. Conclusions：Diarrhea is frequently observed in patients after pancreatoduodenectomy, and the majority of them can be cured with treatment selected according to the pathogenesis.