Abstract:Objective：To discuss the therapeutic effects of rhubarb and natrii sulfas for severe acute pancreatitis(SAP). Methods：Eighty-three patietns with SAP were randomly divided into treatment group(group A, n=45) and control group(group B, n=38). The 2 groups received the same therapy except that group A received rhubarb and natrii sulfas through nasogastric tube. Results： In treatment group compared to control group, the clinical symptoms such as abdominal pain and distention were more quickly relieved, with early return to oral food intake, lesser complications and shorter hospital stay(all with P<0.05).Conclusions：Combined use of rhubarb natrii sulfas for treatment of SAP has a significant therapentic effect.