Abstract:Objective：To assess the application of the biofragmentable anastomosis ring（BAR） in intestinal anastomosis. Methods：One hundred and eighty-six patients who undergoing intestinal anastomosis were randomly allocated to biofragmentable anastomosis ring group (BAR group, n=92) and manual suture group (control group n=94). The restoration time of bowel fanctions, and the post-operative complications related to anastomotic site were recorded in each group. One hundred tweenty-seven patients with colonic carcinoma(62 patients in BAR group and 65 patients in manual group) were followed up post-operatively, and the incidence of inflammatory reactions at the anastomotic site was registered. Results：In 2 patients(2.17%) it was difficult to use the BAR procedure. One mortality was recorded in each group, but were not related to anastomotic procedure. In BAR group and manual group, post-operative bowel restoration time was 61.4±8.6h and 68.3±9.7h respectively(P>0.05). In BAR group and manual group, anastomotic leaks, anastomotic bleeding and obstruction occurred in 1, 2; 2,1 and 0,0 patients respectively(all P>0.05). Anastomotic inflammatory reaction occurred in 2 patients(3.2%) in BAR group and 13 patients(20.0%) in manual group. The difference was statistically significant(P<0.01). Conclusions：BAR is a safe and effective device for intestinal anastomsis.