Abstract:Objective:To investigate the effects of ulinastatin on liver function of patients with cholelithiasis and liver cirrhosis during postoperative period. Methods:Ninty-seven cholelithiasis patients with liver cirrhosis who received surgical treatment in a period of 5 years were randomly divided into control group and therapeutic group. The ulinastatin was given by intravenous drip in the therapeutic group for 3 days postoperatively. The liver function was determined in both groups 1 day before operative and on post operative 1d, 3d, and 5d respectively, and the postoperative complication rate was observed. Results:The postoperative complication rate of therapeutic group was significantly lower and the liver function improvement was obviously better than that of the control group. Conclusions:The use of ulinastatin during the post operative period could protect the liver function and reduce the complication rate in patients with liver cirrhosis receive cholelithiasis surgery.