Abstract:Objective ：To investigate if there is a synergism of kansui root and low molecular weight heparin(LMWH) in combined treatment of SAP in rats. Methods ：SD rats were randomly divided into 5 groups:Sham group(A group), severe acute pancreatitis group(B group), kansui root treatment group(C group), LMWH treatment group(D group), combined treatment group(E group). The serum TNF-α,IL-6 level and the ratio of TXB2/6-keto-PGF1α in pancreatic tissue, and the histological examination were evaluated. Results ：The values ofTNF-α、IL-6 and the ratio ofTXB2/6-keto-PGF1α in C，D，E group were significantly lower than those in B group at the time point of6,12,24h. But there were no significant differences in C，D，E group at all the time points. The histological examination showed that the pancreas was normal in group A; the pathological changes were milder in C，D，E group than that in B group.Conclusions ：Combined treatment of kansui root and LMWH was effective in SAP, but there was no synergism, and also no side effects.