Abstract:Objective ：To explore the effect of gadolinium chloride(Gdcl3) on inflammatory mediators secreted by alveolar macrophages（AMs）in acute necrotizing pancreatitis(ANP) rats. Methods ：Ninty SD rats were randomly into five groups( n =18 in each group): normal control(C) group, ANP group, C+Gdcl3 treatment(C+A) group, ANPGdcl3 pretreatment(AP) group, ANPGdcl3 treatment(AT) group. AMs were obtained by bronchoalveolar lavage. The blood gas the weight ratio of wet/dry lung tissue, the protein content of bronchoalveolar lavage fluids(BALF), the myeloperoxidase(MPO) of lung tissue and secretion of TNFa and NO by AMs were evaluated; histologic examination of lung tissue was performed. Results ：The parameters mentioned above in C+A group compared with C group showed no statistical significance ( P >0.05). Except the blood gas, the indicators mentioned above in AP group and AT treatment group were significantly elevated compared with normal control group( P <0.05); but lewer significantly compared to the ANP group( P <0.05).Conclusions ：Gdcl3 can inhibit the secretion of inflammatory mediators of AMs and ameliorate lung injury of ANP.