Abstract:Objective：To study the clinical prognosis and opportune time for surgical treatment of patients with asymptomatic cholecystolithiasis. Methods：The 10-year B-ultrasound followup observations and the method of treatment of 200 cases of asymptomatic cholecystolithiasis patients were summarized and evaluated. Results：Two cases (1.0%)died of other causes in the 10-year followup period. In 134 patients(67.0%), who did not develop symptoms, 4 patients had prophylactic cholecystectomy, and 130 cases were treated non-operatively. Among them, 64(32.0%) cases who suffered biliary cholic or other biliary complications,49(76.6% of patients with symptoms ) cases underwent cholecystectomy, and 15 cases were treated non-operatively. Conclusions：Some patients with asymptomatic cholecystolithiasis may selectively undergo preventive cholecystectomy to reduce complications.