Abstract:Objective:To investigate the early diagnosis and treatment of duodenal papilla carcinoma. Methods:The clinical data of 71 patients with duodenal papilla carcinoma were analyzed retrospectively. Results:Painless jaundice (57 cases), discomfort of upper abdomen (10 cases) and hemorrhage of upper digestive tract (4 cases) were the initial main clinical symptoms. The correct diagnostic rate for preoperative examinations were: ERCP in 100%, duodenoendoscopy in 96.8%, MRCP in 83.3%, BUS in 85.9% and CT in 72.3% of cases. Forty-six cases underwent pancreatoduodenectomy, 22 cases received local resection, and the remaining 3 cases were treated by palliative surgery. The 3-year survival rate of Whipple operation and local resection was 43.9% and 44.4% respectively, and the 5-year survival rate was 31.7% and 33.3% respectively. Conclusions:Duodenoendoscopy, ERCP and MRCP are the major effective diagnostic methods for duodenal papilla carcinoma. Early diagnosis and early selection of rational radical operation are essential for successul treatment of this condition.