Abstract:Objective:To investigate the risk factors that affect the perioperative mortality in cholangiocarcinoma. Methods:The clinical data of sixty two patients with cholangiocarcinoma who underwent operation were reviewed retrospectively. Logistic regression test was used in the perioperative mortality study. Before multivariate analysis, each parameter was evaluated with univariate analysis to define whether it was of statistical significance (P<0.1) or not. Then the parameters with statistical significance were entered for further multivariate analysis. Results:Univariate analysis showed 7 factors that might influence the perioperative mortality, included age, preoperative total bilirubin, γ-GT, albumin, tumour stage, liver function classification, and preoperative concomitant diseases.In multivariate analysis, results showed that 3 factors significantly influenced the perioperative mortality, which in order of significance were age, tumour stage, and γ-GT. Conclusions:Aging, high γ-GT and late tumour stage are the risk factors, which can increase the perioperative mortality in cholangiocarcinoma.