Abstract:Objective:To explore the effect of intra-and post-operative administration of supplemental high concentration oxygen on abdominal clean-contaminated surgical wound infection.
Methods :From January 2001 to June 2005, 425 patients undergoing abdominal clean-contaminated operation were randomly divided into receive FiO2 60 % (n=213, study group) or FiO2 28 % (n=212, control group) inspired oxygen during the operation and two hours postoperatively. The partial pressure of oxygen in arterial blood and the peripheral arterial oxygen saturation was were measured two hours after operation. During 15 postoperative days, the wounds that drained pus were considered infected.
Results:The results showed that the partial pressure of oxygen in arterial blood was significantly higher in the study group than in the control group （P＜0.001）, and the peripheral arterial oxygen saturation was normal in both groups. Seven(3.29 %) patients in study group had surgical wound infection, as compared with 18(8.49 %) patients in control group (P＜0.05).
Conclusions:The results indicate that perioperative high concentration oxygen supplement can reduce the incidence of infection abdominal clean-contaminated surgical wound.