Abstract:Objective To investigate the expression level of RECK mRNA and MMP9mRNA in breast cancer(BC) and fibroadenoma tissues and its significance. Methods The mRNA level of tissues of 39 cases of breast cancer and 14 cases of fibroadenoma was measured by RTPCR technique and its correlation was analyzed. Results The mRNA level of RECK gene in breast cancer tissues was markedly lower than that in fibroadenoma tissues, while the MMP9 level was higher in BC tissues. Conclusions RECK is a tumor suppressor gene, the expression in benign and malignant breast tissues is a negative relationship. BECK can inhibit the expression of MMP9 and thus, inhibit the growth and metastasis of breast cancer.