Abstract:Objective:To summarze our experience and evaluate the therapeutic effect of hepatectomy for intrahepatic bile duct stones. Methods:The clinical data of 316 patients suffering from intrahepatic lithiasis who underwent hepatectomy from Feb. 1985 to Dec. 2004 were retrospectively analyzed. Stones distribution, operation modality, postoperative complications, and therapeutic effect were evaluated. Among the 316 patients, 192 cases(60.76%) were treated with left lateral hepatectomy, 58 cases（18.35%） with left hemihepatectomy, 12 cases（3.80%）with quadarate lobectomy, 54 cases（17.09%） with right hemihepatectomy or segmentectomy, and 14 cases（4.43%）with left and right segmentectomy. Additional biliary procedures including common bile duct exporation and cholangio-enterostomy were performed in 184 patients（58.23%）. Results:Postoperative complications occurred in 56（17.72%）cases, including biliary fistula, hemobilia, and subdiaphragmatic infections. Three patients（0.95%）died. The follow-up study conducted in 258 patients（81.65%）for an average of 10.3 years showed that excellent results were achieved in 90.31% of the patients. Conclusions:Regular hepatic lobectomy/segmentectomy is the most effective treatment for intrahepatic lithiasis.