Abstract: Objective:To investigate the preventive effect of octreotide combined with sodium hyaluronate on postoperative abdominal adhesions in rabbits.
Methods:The established postoperative abdominal adhesion models were divided into 4 groups:(1)without use of octreotide or sodium hyaluronate (model control group); (2)local application of sodium hyaluraronate(HA group) before closure of abdomen; (3)intraperitoneal injection of octreotide (OC group),(4)local application of sodium hyaluronate and peritoneal injection of octreotide 20ug/kg(OC+HA group). relaparotomy was done 14 days later, and the adhesion extent was judged.
Results:Incidence rates of abdominal adhesion on the day 14 after the operation betweent the 4 groups were not different(P>0.05). However,the incidence rates of severe abdominal adhesion were different(P<0.05). In OC+HA group was significantly lower than that in the model control group、 octreotide group and HA group （P<0.05）; and no significant difference between the octreofid group and sodium hyaluronate group (P>0.05).
Conclusions: Combination of octreotide and sodium hyaluronate have the synergetic preventive action on the degree and rate of formation of severe peritoneal adhesions after abdominal operation in rabbits