结直肠癌患者IL-6基因启动子-174G→C多态性研究
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    李登清


    Investigation of -174G→C polymorphism of the IL-6 gene promoter in patients with colorectal cancer
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      摘要:

      目的:观察结直肠癌患者是否存在IL-6基因启动子-174G→C位点的多态性。
      方法:采用PCR扩增、限制性内切酶片段长度多态性(RFLP)分析判断46例结直肠患者IL-6启动子-174G→C多态性。
      结果:全组结直肠癌患者IL-6基因启动子-174位点均为GG型。
      结论:本组结直肠癌患者中未发现IL-6基因启动子-174位点的多态性。

      Abstract:

      Abstract:Objective:To detect -174G→C polymorphism of IL-6 gene promoter in patients with colorectal cancer.
      Methods :-174G→C polymorphism of IL-6 gene promoter was detected by PCR-RFLP in 49 patients with colorectal cancer.
      Results:-174G→C polymorphism of IL-6 gene promoter in all the 46 patients with colorectal cancer was -174G/G genotype.
      Conclusions:-174G→C polymorphism of IL-6 gene promoter was not found in 49 patients with colorectal cancer.

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    陈江辉, 李登清, 陈子华.结直肠癌患者IL-6基因启动子-174G→C多态性研究[J].中国普通外科杂志,2007,16(4):12-.
    DOI:10.7659/j. issn.1005-6947.2007.04.012

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    • 在线发布日期: 2007-04-25