Abstract:Objective：To evaluate the therapeutic effect of neoadjavunt chemotherapy for gastric carcinoma.
Methods ：Forty-eight gastric carcinoma patients(stage IIIb and IV) were selected. Pre-operatively, they received a two-week regimen of oxaliplatin,5-Fu and CF. After 2-3 cycles treatment, CT and gastroscopy were used to determine resectability and then operation was performed.
Results：The total efficiency of neoadjuvant chemotherapy was 58.4%， while it was 64.1% for stage IIIb and 22.2% for stage IV cases. In 39 stage III patients，the radical resection rate was71.8%。In 9 stage IV patients，2 were received palliative resection and one underwent simple abdominal exploration.
Conclusions：Neoadjuvant chemotherapy could effectively increase the radical resection rate of stage III gastric carcinoma patients, but the therapeutic effect was not significant for stage IV patients.