Abstract:Objective:To investigate the effect of PSUPER-siRNA-IGFIR plasmid in inhibiting the growth of human liver cancer cell SMMC7721.
Methods:Cancer xenograft was established by transplanting SMMC7721 cell to nude mice, and the PSUPER-siRNA-IGFIR plasmid was constructed and the graft cancer was treated with PSUPER-siRNA-IGFIR plasmid. The effect on tumor growth was monitored.
Results:PSUPER-siRNA-IGFIR plasmid can inhibit the growth of human liver cancer cell SMMC7721. The expression of IGFIR and MVD in human liver cancer cell SMMC7721 was decreased significantly in the gene transfected group as compared to that of control group.
Conclusions:The PSUPER-siRNA-IGFIR plasmid can inhibit the growth of human transfected liver-cancer in nude mice.