Abstract:Objective:To compare the clinicopathologic characters and survival rates between upper and lower part gastric carcinoma.
Methods :The clinicopathologic data of 73 patients with upper part gastric carcinoma (group U) and 366 patients with lower part gastric carcinoma (group L) were analyzed retrospectively.
Results:The clinicopathologic characteristics in group U were more male patients（P<0.01）, more tumor diameter larger than 5 cm（P<0.05）, more diffused tumor growth（P<0.05）, more T3 and T4 stages （P<0.05）, more N2+N3 stage（P<0.05）, more undifferentiated type（P<0.05） and less patients with degree A excision （P<0.05） than those in group L. Median survival time was 42 months in group U and 60 months in group L, and 5-year survival rate in group U was significantly lower than that in group L（P<0.01）.
Conclusions:The patients in guoup U showed many differences compared with patients in group L, including more male patients, larger tumor diameter, diffused tumor growth, less early stage, later TNM stage, more lymph node metastasis, more undifferentiated type, and less radical operation. The survival rate in group U was significantly lower than in group L. Accordingly, the main treatment for the upper gastric carcinoma should be surgical excision as chief component of combined therapy.