规范急诊流程下破裂腹主动脉瘤腔内修复的近、中期疗效
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云南省阜外心血管病医院/昆明医科大学附属心血管病医院 血管外科,云南 昆明650102

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肖悦,昆明医科大学附属心血管病医院/云南省阜外心血管病医院硕士研究生,主要从事血管外科方面的研究。

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云南省科技厅重点研发计划基金资助项目(202403AC100004)。


Short- and mid-term outcomes of endovascular repair for ruptured abdominal aortic aneurysms under standardized emergency protocols
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Department of Vascular Surgery, Fuwai Yunnan Hospital, Chinese Academy of Medical Sciences/Affiliated Cardiovascular Hospital of Kunming Medical University, Kunming650102, China

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    摘要:

    背景与目的 腹主动脉瘤破裂(rAAA)是腹主动脉瘤最严重的并发症,病情发展迅速,病死率高,及时的诊断和治疗极其关键,目前腔内治疗作为一线选择。本文分析探讨规范急救流程下动脉瘤腔内修复术(EVAR)治疗rAAA的安全性、有效性,以及近、中期疗效。方法 回顾性分析2018年1月—2024年10月在云南省阜外心血管病医院接受EVAR的22例rAAA患者的临床资料。男16例,女6例,年龄(67.2±10.0)岁,瘤体最大径(70.6±9.2)mm,均为肾下型rAAA,瘤颈角度(107.9±54.3)°。所有患者术前均通过全主动脉+冠脉CT血管造影(CTA)确诊,所有患者在规范急救流程下行EVAR。收集患者围手术期临床资料,术后1周与1、6、12个月及之后每年1次随访CTA资料,分析瘤腔血栓化率、支架形态、内漏形式及发生率、髂分支通畅率等。结果 手术成功率为100%;术中支架植入后造影发生Ⅰ型内漏6例,通过球囊扩张、植入短支架及弹簧圈+生物蛋白胶填充瘤腔等技术处理,再次造影内漏消失或明显减少。平均手术时间(162.1±63.6)min,输悬浮红细胞(736.4±532.3)mL,术后外科重症监护病房治疗时间(8.76±1.0)h,平均住院时间(8.1±4.5)d。术后30 d死亡6例,2例患者术后1周复查CTA发现少许Ⅱ型内漏,未予特殊处理,术后1个月复查内漏减少,术后3~6个月,内漏消失;1例患者于术后2年发生Ⅰb型内漏,遂二次干预,内漏消失;其余患者支架无内漏,无髂支闭塞,瘤腔血栓化程度满意。结论 规范急救流程下EVAR治疗rAAA安全有效,近中期疗效满意,对于Ⅰ型内漏可借助球囊扩张、植入短支架及弹簧圈+生物蛋白胶填充瘤腔等技术予以处理,疗效安全可靠。

    Abstract:

    Background and Aims Ruptured abdominal aortic aneurysm (rAAA) is the most severe complication of abdominal aortic aneurysms, characterized by rapid progression and high mortality. Timely diagnosis and treatment are critical, with endovascular aneurysm repair (EVAR) currently serving as the first-line treatment. This study was conducted to evaluate the safety, efficacy, and short- to mid-term outcomes of EVAR for rAAA under standardized emergency protocols.Methods The clinical data of 22 patients with rAAA who underwent EVAR at Yunnan Fuwai Cardiovascular Hospital from January 2018 to October 2024 were retrospectively analyzed. The cohort included 16 males and 6 females, with a mean age of (67.2±10) years. The mean maximum aneurysm diameter was (70.6±9.2) mm, and all cases were infrarenal rAAA with a mean aneurysm neck angle of (107.9±54.3)°. All patients were diagnosed preoperatively via total aortic and coronary computed tomography angiography (CTA) and treated with EVAR under standardized emergency protocols. Perioperative clinical data, along with follow-up CTA findings at 1 week, 1 month, 6 months, 12 months, and annually thereafter, were collected. Outcome measures included aneurysm sac thrombosis rate, stent morphology, type and incidence of endoleaks, and iliac branch patency rate.Results The procedural success rate was 100%. Intraoperative angiography revealed type I endoleak in 6 cases, which were successfully managed using balloon dilation, short stent implantation, or a combination of coil embolization and biologic glue to seal the aneurysm sac. Post-treatment angiography showed resolution or significant reduction of the endoleak. The mean operative time was (162.1±63.6) min, with an average transfusion of (736.4±532.3) mL of packed red blood cells. After operation, the average stay in the SICU was (8.76±1.0) h, and the mean hospital stay was (8.1±4.5) d. There were 6 deaths within 30 d after operation. Two patients had minor type Ⅱ endoleak detected on CTA at 1 week, which required no special intervention; these endoleaks reduced by 1 month and resolved by 3-6 months. One patient developed a type Ib endoleak at 2 years after operation, which was successfully managed with reintervention. The remaining patients had no endoleaks, no iliac branch occlusions, and satisfactory aneurysm sac thrombosis.Conclusion EVAR under standardized emergency protocols is safe and effective for treating rAAA, with satisfactory short- and mid-term outcomes. Type Ⅰ endoleak can be reliably managed using techniques such as balloon dilation, short stent implantation, and coil embolization with biologic glue, demonstrating a safe and effective treatment approach.

    图1 rAAA患者规范化急救流程图Fig.1 Standardized emergency protocol for rAAA patients
    图2 CTA资料 A:瘤颈严重扭曲;B:术后3 d,瘤体内存在少量内漏;C:术后1周,内漏消失Fig.2 CTA findings A: Severe tortuosity of the aneurysm neck; B: Minimal endoleak within the aneurysm sac 3 d after operation; C: Resolution of the endoleak 1 week after operation
    图3 术中造影资料 A:术中经肱动脉途径将导丝送入左髂动脉,抓捕器抓出导丝,建立左侧髂腿通路;B:支架植入后造影可见I型内漏;C:经预留的椎动脉导管在瘤颈周边置入可控弹簧圈+生物蛋白胶,CODA球囊充分扩张;D:再次造影,Ⅰ型内漏明显减少Fig.3 Intraoperative angiography findings A: Guidewire advanced into the left iliac artery via the brachial artery and retrieved using a snare to establish the left iliac limb pathway; B: Angiography after stent deployment showing type I endoleak; C: Controlled coil embolization with biologic glue applied around the aneurysm neck via the reserved vertebral artery catheter, followed by full expansion with a CODA balloon; D: Repeat angiography showing a significant reduction in the type I endoleak
    图4 CTA重建资料 A:术前CTA重建图像;B:通过GE工作站充分展开瘤颈,预判机位;C:术后1周CTA重建图像Fig.4 CTA reconstruction images A: Preoperative CTA reconstruction; B: Aneurysm neck fully expanded and operative position pre-assessed using the GE workstation; C: Postoperative CTA reconstruction at 1 weekn
    表 2 22例患者手术相关情况Table 2 Surgery-related data of 22 patients
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肖悦,郭媛媛,郭修海,陈澄.规范急诊流程下破裂腹主动脉瘤腔内修复的近、中期疗效[J].中国普通外科杂志,2024,33(12):1975-1982.
DOI:10.7659/j. issn.1005-6947.2024.12.005

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  • 收稿日期:2024-11-05
  • 最后修改日期:2024-12-20
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  • 在线发布日期: 2025-01-14