Background and Aims Abdominal aortic aneurysm (AAA) is a disease with high morbidity and mortality in elderly patients. The actions of endogenous competing RNA (ceRNA) networks in the underlying pathogenesis of AAA are unclear at present. Therefore, this study was conducted to investigate the role of ceRNA network in the formation and development of AAA through screening and establishing the AAA-specific long non-coding RNA (lncRNA)-microRNA (miRNA)-mRNA ceRNA network.Methods Firstly, the data set was screened in gene expression database (GEO), and the differentially expressed lncRNAs and mRNAs between AAA and normal abdominal aorta tissues were identified. Lasso regression was used to screen the disease characteristic genes from differentially expressed RNAs. Starbase software was used to search for miRNAs that combined with differentially expressed lncRNAs and specific mRNAs, and Cytoscape software was used to construct the lncRNA-miRNA-mRNA ceRNA network. The cytohubba module in Cytoscape was used to further screen the core ceRNA network.Results Two data sets GSE7084 and GSE57691 were screened, and 144 differentially expressed mRNAs and 13 differentially expressed lncRNAs were obtained. Seventeen specific mRNAs were obtained from differentially expressed mRNAs by Lasso regression. lncRNA HCP5-miR27-FOSB was considered be the most critical ceRNA network for the occurrence and development of AAA.Conclusion The constructed ceRNA network may be involved in the formation and development of AAA. However, this result still needs to be further investigated and verified by subsequent studies.